Hochhut B, Lotfi Y, Mazel D, Faruque SM, Woodgate R, Waldor MK. Analysis of antibiotic resistance regions in Gram-negative bacteria. Origins and evolution of antibiotic resistance. Inverse correlation between promoter strength and excision activity in class 1 integrons.

Jove T, Da Re S, Denis F, Mazel D, Ploy MC. Integron integrases possess a unique additional domain necessary for activity. Integrons and gene cassettes: hotspots of diversity in bacterial genomes. Integrons: mobilizable platforms that promote genetic diversity in bacteria. Annu Rev Genet 2010 44:141-166.Ĥ.Boucher Y, Labbate M, Koenig JE, Stokes HW. Antimicrobial resistance: a global multifaceted phenomenon. Antimicrobial resistance: a global emerging threat to public health systems. Ferri M, Ranucci E, Romagnoli P, Giaccone V. Our analysis showed that measures such as estimates of the prevalence of this transposable element and diligence in continued surveillance might be necessary to prevent its spread.ġ. The frequencies of class 1 integron in MDR (79%) and non-MDR isolates (41%) were higher than those for class 2 integron in MDR (13.4%) and non-MDR isolates (17.7%).Ĭonclusion: The current systematic review demonstrated the significant presence of integrons among clinical isolates. The highest prevalence of integron class 1 was reported in Acinetobacter spp (58%) while the highest prevalence of integron class 2 was reported in Shigella isolates (83.7%). Results: In a comprehensive literature review, 29 eligible studies were determined with their meta-analyses indicating the prevalence of integron class 1 to be 41% (95% CI 36.3-46.1) and integron class 2 as 17.7% (95% CI 13-23.3) in Gram-negative bacteria. The raw data for integrons among bacterial isolates were collected and their prevalence was analyzed using Comprehensive Meta-Analysis V2.0 (Biostat, Englewood, NJ, USA) software. Materials and Methods: Electronic global databases were systematically searched. The objective of the present study was to determine the frequency of different classes of integrons in clinical isolates in Iran.

It is known that the high prevalence of integrons in multidrug-resistant (MDR) clinical isolates has become a serious public health concern. Objective(s): Integrons, as a potential element in the distribution and maintenance of drug resistance, have thoroughly been established.

Comprehensive meta analysis v2